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Functional coexpression of excitatory mGluR1 and mGluR5 on striatal cholinergic interneurons
A Pisani1, P Bonsi, D Centonze
1Clinica Neurologica, Dipartimento di Neuroscienze, Università di Roma "Tor Vergata", Rome, Italy. pisani@uniroma2.it
Neuropharmacology
|February 13, 2001
Summary
Group I metabotropic glutamate receptors (mGluRs) activate striatal cholinergic interneurons. Both mGluR1 and mGluR5 appear to mediate this excitatory effect, as shown by antagonist studies.
Area of Science:
- Neuroscience
- Neuropharmacology
Background:
- Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors modulating neuronal excitability.
- Striatal cholinergic interneurons play key roles in motor control and reward processing.
Purpose of the Study:
- To investigate the involvement of mGluR1 and mGluR5 in the activation of striatal cholinergic interneurons.
Main Methods:
- Electrophysiological recordings of striatal cholinergic interneurons.
- Application of selective mGluR agonists: (S)-3,5-dihydroxyphenylglycine (3,5-DHPG) and 2-chloro-5-hydroxyphenylglycine.
- Co-application of mGluR1 and mGluR5 antagonists.
Main Results:
- Both 3,5-DHPG (group I mGluR agonist) and a selective mGluR5 agonist induced membrane depolarization in striatal cholinergic interneurons.
- The excitatory response to 3,5-DHPG was abolished only when both mGluR1 and mGluR5 antagonists were co-administered.
Conclusions:
- Group I mGluRs, specifically mGluR1 and mGluR5, contribute to the excitatory control of striatal cholinergic interneurons.
- These findings highlight a potential therapeutic target for modulating striatal function.