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Related Experiment Videos

Formulation of shear rate sensitive multiple emulsions.

V Muguet1, M Seiller, G Barratt

  • 1Laboratoire de Dermopharmacologie et Cosmétologie, UMR CNRS 8612, 5 rue J.B. Clément, 92296 Châtenay-Malabry, Cedex 14, France.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|February 13, 2001
PubMed
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This study developed water-in-oil-in-water (W/O/W) multiple emulsions for controlled release applications. The emulsions effectively release inner aqueous phases under specific shear rates, applicable across industries.

Area of Science:

  • Colloid and Surface Science
  • Materials Science
  • Chemical Engineering

Background:

  • Multiple emulsions (W/O/W) offer unique delivery systems for active ingredients.
  • Controlled release mechanisms are crucial for agroalimentary, pharmaceutical, and cosmetic industries.
  • Understanding droplet behavior under shear is key to designing effective W/O/W emulsions.

Purpose of the Study:

  • To formulate W/O/W multiple emulsions with shear-induced release capabilities.
  • To investigate the impact of external phase composition on emulsion fragmentation and release kinetics.
  • To validate the applicability of Taylor's theoretical framework to these shear-sensitive emulsions.

Main Methods:

  • Formulation of three types of W/O/W multiple emulsions: non-viscosified, Carbopol 974P((R)) gelled, and hydroxypropylcellulose thickened.

Related Experiment Videos

  • Characterization of emulsion behavior under varying shear rates.
  • Analysis of droplet bursting mechanisms using established theoretical models.

    • Main Results:

    • Emulsion composition significantly influences fragmentation and release profiles as a function of shear rate.
    • All tested W/O/W emulsions demonstrated shear-induced release of their internal aqueous phase.
    • The study confirmed that droplet bursting mechanisms align with Taylor's theoretical framework, irrespective of emulsion formulation.

    Conclusions:

    • W/O/W multiple emulsions can be engineered for controlled release triggered by shear stress.
    • The choice of external phase thickener (e.g., Carbopol, hydroxypropylcellulose) modulates release characteristics.
    • Taylor's theory provides a robust framework for predicting the shear-induced rupture of W/O/W emulsion globules.