Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Salt and cosolvent effects on ionic drug loading into microspheres using an O/W method.

A Al-Maaieh1, D R Flanagan

  • 1Division of Pharmaceutics, College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|February 13, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cocrystal intrinsic dissolution behavior using a rotating disk.

Journal of pharmaceutical sciences·2011
Same author

Inoculation of female American black bears (Ursus americanus) with partially purified porcine zona pellucidae limits cub production.

Reproduction, fertility, and development·2007
Same author

Persistence of anti-zonae pellucidae antibodies following a single inoculation of porcine zonae pellucidae in the domestic equine.

Reproduction (Cambridge, England)·2005
Same author

Porcine zona pellucida (PZP) immunocontraception of wild horses (Equus caballus) in Nevada: a 10 year study.

Reproduction (Cambridge, England). Supplement·2002
Same author

Drug transfer through mucus.

Advanced drug delivery reviews·2001
Same author

FTIR-ATR spectroscopy for monitoring polyanhydride/anhydride-amine reactions.

Journal of controlled release : official journal of the Controlled Release Society·2000

Adding specific salts to Poly-D,L-lactic acid (PLA) microsphere formulations significantly enhances drug loading by reducing the aqueous solubility of ionic drugs. This method improves drug entrapment efficiency in microspheres for better drug delivery.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Microsphere drug delivery systems offer controlled release advantages.
  • Optimizing drug entrapment efficiency in Poly-D,L-lactic acid (PLA) microspheres is crucial for effective therapeutic outcomes.
  • Ionic drug solubility in aqueous and organic phases influences formulation performance.

Purpose of the Study:

  • To investigate the impact of various salts on the aqueous solubility of quinidine sulfate.
  • To determine how salt addition affects the entrapment efficiency of quinidine sulfate in PLA microspheres.
  • To explore the role of solvent properties and cosolvents in microsphere preparation.

Main Methods:

  • Poly-D,L-lactic acid (PLA) microspheres were prepared using an oil-in-water (O/W) solvent evaporation technique.

Related Experiment Videos

  • Electrolytes were added to the aqueous phase at varying concentrations to study salt effects.
  • Solubility of quinidine sulfate and dichloromethane (DCM) was measured in the presence of different salts.
  • Microsphere drug loading and drug distribution were analyzed.

    • Main Results:

    • Specific inorganic salts, such as NaClO(4) and NaSCN, significantly depressed quinidine sulfate aqueous solubility, leading to high drug loading (>90%) in PLA microspheres.
    • The common ion effect (Na(2)SO(4)) and formation of less soluble drug salts influenced drug solubility and loading.
    • Inorganic salts decreased dichloromethane (DCM) aqueous solubility according to the Hofmeister series.
    • Incorporation of a cosolvent (ethanol) into the organic phase improved drug loading and microsphere uniformity.

    Conclusions:

    • Salt selection is a critical factor in optimizing ionic drug loading in PLA microspheres.
    • Manipulating aqueous solubility through salt addition is an effective strategy to enhance drug entrapment efficiency.
    • Cosolvents can further improve microsphere characteristics and drug release profiles.