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Related Concept Videos

Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation. 
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

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Related Experiment Video

Updated: Jul 14, 2026

Investigating Intestinal Inflammation in DSS-induced Model of IBD
08:43

Investigating Intestinal Inflammation in DSS-induced Model of IBD

Published on: February 1, 2012

Coagulation studies in ulcerative colitis and Crohn's disease.

A Lam, I T Borda, M J Inwood

    Gastroenterology
    |February 1, 1975
    PubMed
    Summary

    Inflammatory bowel diseases like ulcerative colitis and Crohn's disease are linked to blood clotting abnormalities. Both conditions show increased clotting factors and platelet counts, alongside decreased antithrombin III levels.

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    Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
    09:11

    Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

    Published on: February 14, 2021

    Area of Science:

    • Gastroenterology
    • Hematology
    • Internal Medicine

    Background:

    • Thromboembolic disease is a recognized complication of ulcerative colitis.
    • Thromboembolic events are infrequently reported in Crohn's disease patients.
    • The hemostatic balance in inflammatory bowel diseases requires further investigation.

    Purpose of the Study:

    • To investigate potential coagulation abnormalities in patients with ulcerative colitis and Crohn's disease.
    • To compare coagulation profiles between inflammatory bowel disease patients and healthy controls.

    Main Methods:

    • A comparative study involving four groups: ulcerative colitis patients, Crohn's disease patients, patients with other diseases, and healthy controls.
    • Analysis of platelet counts, coagulation factors (Factor V, Factor VIII), fibrinogen levels, and antithrombin III levels.

    Main Results:

    • Elevated platelet counts were observed in both ulcerative colitis and Crohn's disease groups.
    • Increased levels of Factor V, Factor VIII, and fibrinogen were detected in both patient cohorts.
    • Decreased antithrombin III levels were noted in patients with ulcerative colitis and Crohn's disease.

    Conclusions:

    • Coagulation abnormalities, including a prothrombotic state, are present in both ulcerative colitis and Crohn's disease.
    • These findings suggest a potential link between inflammatory bowel diseases and an increased risk of thromboembolic events.
    • Further research is warranted to elucidate the clinical implications of these hemostatic changes.