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Cluster headache.

D W Dodick1, T D Rozen, P J Goadsby

  • 1Mayo Clinic, Scottsdale, AZ, USA.

Cephalalgia : an International Journal of Headache
|February 13, 2001
PubMed
Summary
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Cluster headache involves severe, unilateral head pain with autonomic symptoms, likely stemming from hypothalamic dysfunction. This review covers its clinical features, causes, gender variations, and treatments.

Area of Science:

  • Neurology
  • Neuroscience
  • Pain Medicine

Background:

  • Cluster headache is a debilitating primary headache disorder characterized by severe unilateral head pain and autonomic symptoms.
  • The pathophysiology is thought to involve the circadian hypothalamic generator and trigeminovascular system activation.

Purpose of the Study:

  • To review the clinical manifestations, pathophysiology, gender differences, and treatment options for cluster headache.

Main Methods:

  • Literature review of clinical manifestations, pathophysiology, gender differences, and treatment options for cluster headache.

Main Results:

  • Cluster headache presents with stereotypic, short-lasting attacks of severe unilateral head pain.
  • Associated autonomic symptoms are common during attacks.

Related Experiment Videos

  • Hypothalamic abnormalities and trigeminovascular activation are implicated in its cause.

    • Conclusions:

    • Understanding the clinical picture, underlying mechanisms, and gender-specific aspects is crucial for effective cluster headache management.
    • Comprehensive review highlights the need for targeted therapeutic strategies.