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Two new SUNCT cases responsive to lamotrigine.

M Leone, A Rigamonti, S Usai

    Cephalalgia : an International Journal of Headache
    |February 13, 2001
    PubMed
    Summary
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    Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) is a rare headache. Lamotrigine showed success in preventing SUNCT attacks in two patients, offering hope for an effective treatment.

    Area of Science:

    • Neurology
    • Headache Medicine

    Background:

    • Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) is a rare and debilitating headache disorder.
    • SUNCT is often refractory to established headache treatments.

    Observation:

    • A recent report suggested lamotrigine may be effective for SUNCT.
    • This study investigated lamotrigine's efficacy in two new SUNCT patients.

    Findings:

    • Lamotrigine prophylaxis was successful in both SUNCT patients.
    • The medication effectively prevented headache attacks.

    Implications:

    • Lamotrigine may represent the first effective prophylactic treatment for SUNCT.
    • Further research is warranted to confirm lamotrigine's role in managing this rare headache syndrome.

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