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Hypertension is a major risk factor for aortic root dilatation in women with Turner's syndrome

M Elsheikh1, B Casadei, G S Conway

  • 1Department of Endocrinology, Radcliffe Infirmary, Woodstock Road, Oxford, OX2 6HE, UK.

Clinical Endocrinology
|February 13, 2001
PubMed

Insights

Women with Turner's syndrome (TS) face higher mortality from cardiovascular issues. This study found aortic root dilatation in 42% of TS patients, linked to hypertension and bicuspid aortic valves, necessitating regular screening.

Area of Science:

  • Cardiology
  • Genetics
  • Internal Medicine

Background:

  • Turner's syndrome (TS) is associated with a threefold increase in mortality, predominantly due to cardiovascular complications.
  • Aortic dissection represents a significant and potentially fatal cause of mortality in women with TS.

Purpose of the Study:

  • To determine the prevalence of aortic root dilatation in women with Turner's syndrome.
  • To identify factors contributing to the development of aortic root dilatation in this population.

Main Methods:

  • Clinical examination and echocardiography (M-mode and 2D) were performed on 38 women with TS.
  • Aortic root dilatation was defined as a diameter exceeding the 95th percentile for body surface area.
  • Serum lipid profiles and central arterial stiffness were assessed; hypertension and bicuspid aortic valves were noted.

Main Results:

  • 42% of women with TS exhibited ascending aortic root dilatation.
  • Aortic root dilatation was significantly associated with systolic blood pressure and left ventricular thickness.
  • Hypertension was present in 50% of subjects, and 33% had a bicuspid aortic valve.

Conclusions:

  • Aortic root dilatation is a prevalent and significant risk in women with Turner's syndrome, strongly correlated with blood pressure.
  • The findings suggest a mesenchymal defect rather than atherosclerosis contributes to aortic dilatation.
  • Regular monitoring of aortic root diameter and aggressive management of hypertension are crucial for preventing aortic dissection in TS patients.

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