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Morphometric evaluation of the human prostate.

M I Arenas1, E Romo, M Royuela

  • 1Department of Cell Biology and Genetics, University of Alcalá, Madrid, Spain.

International Journal of Andrology
|February 13, 2001
PubMed
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Ageing significantly alters prostate histology. Normal prostates become rare after 70, with stromal expansion in the central region. Pathological changes like hyperplasia and cancer also show age-related volume variations.

Area of Science:

  • Urology
  • Pathology
  • Gerontology

Background:

  • Prostate aging involves complex histological changes.
  • Quantitative data on age-related prostate volume and composition are limited.

Purpose of the Study:

  • To quantitatively analyze age-related histological and volumetric changes in the human prostate.
  • To correlate these changes with common prostatic conditions.

Main Methods:

  • Autopsy prostates from 281 men (20-84 years) were analyzed.
  • Prostates were classified: normal, nodular hyperplasia, intraepithelial neoplasia (PIN), and low-grade carcinoma.
  • Quantitative morphometry assessed regional volumes and stromal/epithelial proportions.

Main Results:

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  • Normal prostates showed increased total and central region volume with age, primarily due to stromal expansion after 30.
  • Normal prostates were absent in men over 70.
  • Nodular hyperplasia appeared after 30; PIN and carcinoma were observed >20, with significant volume increases in the 8th decade.

Conclusions:

  • Prostate aging is characterized by stromal growth and a decline in histologically normal tissue after 70.
  • Age-related changes likely predispose to or influence the development of prostatic hyperplasia and carcinoma.