Some local and systemic immunological features of prepubertal periodontitis
Related Experiment Video
Updated: Oct 9, 2026

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network
Published on: February 16, 2016
T Berglundh1, B Wellfelt, B Liljenberg
1Department of Periodontology, Göteborg University, Sweden. berglundh@odontologi.gu.se
Objectives:
The aim of the present investigation was to study local (gingival) and systemic host defense characteristics in a sample of children exhibiting local prepubertal periodontitis (LPP).
Material And Methods:
2 groups of subjects were included in the present study. One group consisted of 11 children (9.5+/-2.0 years) with signs of periodontal disease (LPP group). A 2nd group comprised 21 adults (48.1+/-5.8 years) with advanced periodontal disease: adult periodontitis (AP) group. Gingival biopsies and a sample of peripheral blood were obtained in each individual of the AP group and in 7 out of the 11 subjects in the LPP group. The biopsies were prepared for morphometrical and immunohistochemical analysis and the blood samples prepared for immunohistochemical analysis.
Results:
The cellular infiltrates in the biopsies of the LPP group contained a larger proportion of lymphocytes and, in particular B cells, than was the case in the AP group. The TCR Valpha/Vbeta gene expression in the lesions in the AP group was dominated by Vbeta 17 and in the LPP group by Valpha2. The content in peripheral blood of various lymphocyte sub-populations and TCR Valpha/Vbeta gene expression in the 2 groups was almost similar.
Conclusion:
It is suggested that (i) the systemic host response in children with prepubertal periodontitis has many features in common with that seen in adult patients but that (II) local defense mechanisms in the periodontitis lesion of LPP differ from those in adult periodontitis.
Related Concept Videos
Development of the Oral Microbiota
The Oral Microbiota
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Acne Infection

