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Updated: Jul 19, 2026
12:43
Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
Published on: January 6, 2014
Cervical cancer vaccines: emerging concepts and developments.
D M Da Silva1, G L Eiben, S C Fausch
1Cancer Immunology Program, Cardinal Bernardin Cancer Center, Loyola University Chicago, 2160 First Avenue, Maywood, Illinois 60143, USA.
Journal of Cellular Physiology
|February 13, 2001
Summary
Human papillomavirus (HPV) causes cervical cancer. Therapeutic and prophylactic HPV vaccines are being developed to treat and prevent HPV infections and related cancers.
Area of Science:
- Oncology
- Virology
- Immunology
Background:
- Certain human cancers are linked to oncogenic viruses.
- Human papillomavirus (HPV) is implicated in cervical cancer pathogenesis.
- Immune response to cancer cells influences disease outcomes.
Purpose of the Study:
- To review the development of HPV vaccines for cervical cancer.
- To discuss both prophylactic and therapeutic vaccine strategies.
- To highlight the role of HPV in cervical cancer development.
Main Methods:
- Review of existing literature on HPV vaccines.
- Analysis of candidate vaccines in preclinical and clinical trials.
- Examination of vaccine efficacy and development status.
Main Results:
- HPV is a necessary cause of cervical cancer, presenting a target for vaccines.
- Both preventive (prophylactic) and treatment (therapeutic) vaccines are under development.
- Various candidate HPV vaccines are progressing through animal models and human trials.
Conclusions:
- HPV vaccines offer a promising strategy for cervical cancer prevention and treatment.
- Development of effective prophylactic vaccines can reduce cervical neoplasia incidence.
- Therapeutic vaccines hold potential for treating existing cervical cancer patients.
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