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Detecting treatment-by-centre interaction in multi-centre clinical trials

R F Potthoff1, B L Peterson, S L George

  • 1Cancer Center Biostatistics, Duke University Medical Center, P.O. Box 3958, Durham, North Carolina 27710, USA. dpotthoff@ccstat.mc.duke.edu

Statistics in Medicine
|February 13, 2001
PubMed

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Therapeutic Drug Monitoring: Affecting Factors

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Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which child was...