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Related Experiment Videos

Mortality in dry-cleaning workers: an update.

A M Ruder1, E M Ward, D P Brown

  • 1National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. amr2@cdc.gov

American Journal of Industrial Medicine
|February 15, 2001
PubMed
Summary
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Dry-cleaning workers exposed to perchloroethylene (PCE) showed increased cancer mortality. Findings suggest a link between PCE exposure and elevated risks for several cancer types, confirming previous research.

Area of Science:

  • Occupational Health
  • Environmental Epidemiology
  • Toxicology

Background:

  • A cohort of 1,708 dry-cleaning workers with at least one year of exposure before 1960 to perchloroethylene (PCE) and Stoddard solvent was studied.
  • Perchloroethylene (PCE) is a known animal carcinogen and probable human carcinogen.

Purpose of the Study:

  • To investigate cancer mortality among dry-cleaning workers exposed to perchloroethylene (PCE).
  • To confirm and update previous findings on the health effects of occupational PCE exposure.

Main Methods:

  • Vital status of the cohort was tracked through 1996.
  • Life table analyses were employed to assess mortality rates and standardized mortality ratios (SMRs).

Main Results:

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  • The cohort experienced excess cancer mortality, with an overall SMR of 1.25 (95% CI 1.11-1.41).
  • Statistically significant elevated SMRs were observed for cancers of the tongue, bladder, esophagus, intestine, lung, and cervix.
  • Increased mortality was also noted for pneumonia and diseases of the stomach and duodenum.

Conclusions:

  • This study corroborates prior research indicating elevated cancer mortality in dry-cleaning workers.
  • Excess mortality at specific sites, particularly in the PCE-only subcohort and among those with longer exposure durations, suggests a potential association with PCE exposure.
  • While lifestyle factors are acknowledged, the findings point towards PCE as a contributing factor to observed cancer risks.