Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja
M Frédérich1, M De Pauw, C Prosperi
1Laboratory of Pharmacognosy, Institute of Pharmacy, University of Liège, CHU, Tour 4, Avenue de l'Hôpital 1, B-4000 Liège, Belgium. M.Frederich@ulg.ac.be
Abstract:
A reinvestigation of Strychnos icaja roots has resulted in the isolation of two tertiary quasi-symmetric bisindole alkaloids named strychnogucines A (1) and B (2). Their structures were identified by means of spectroscopic data interpretation. Compound 2 was highly active in vitro and compound 1 moderately active against four strains of Plasmodium falciparum. Strychnogucine B (2) was more active against a chloroquine-resistant strain than against a chloroquine-sensitive one (best CI(50), 80 nM against the W2 strain). In addition, this compound showed a selective antiplasmodial activity with 25-180 times greater toxicity toward P. falciparum, relative to cultured human cancer cells (KB) or human fibroblasts (WI38).
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