Related Experiment Videos
Additional cytotoxic polyacetylenes from the marine sponge Petrosia species
1College of Pharmacy, Pusan National University, Pusan 609-735, Korea, Korea Research Institute of Chemical Technology, Taejon, Korea.
Journal of Natural Products
|February 15, 2001
Abstract:
Ten new polyacetylenic alcohols (1-6, 8-11), along with a known compound, petrocortyne C (7), were isolated from the marine sponge Petrosia sp. The gross structures were established based on NMR and MS data, and the absolute configuration was determined by the modified Mosher's method. These compounds displayed considerable cytotoxicity against a small panel of human solid tumor cell lines. Compounds 1-11 were further evaluated for in vitro inhibitory activity on DNA replication.