Related Experiment Videos
Kynurenine aminotransferase I activity in human placenta
P Milart1, E M Urbanska, W A Turski
1Department of Gynecology, Medical University of Lublin, Jaczewskiego 8, PL-20090 Lublin, Poland. milart@eskulap.am.lublin.pl
Placenta
|February 15, 2001
Abstract:
The aim of the study was to detect and characterize placental kynurenine aminotransferase I (KAT I) activity in physiological pregnancy at term. Placental KAT I was inhibited by l -glutamine, l -tryptophan, and l -phenylalanine and reached optimum activity at pH 9.8. When pyruvate was used as a co-factor, the KAT I activity was significantly higher than the activity of this enzyme in the presence of 2-oxoglutarate. In the light of our findings placental KAT I seems to have biochemical characteristics of KAT I detected in human brain.