Jove
Visualize
Contact Us

Related Experiment Videos

Nontyphoidal salmonellosis.

E L Hohmann1

  • 1Infectious Diseases Division, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA. ehohmann@partners.org

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|February 15, 2001
PubMed
Summary

Nontyphoidal Salmonella infections pose significant risks, especially to immunocompromised individuals. Emerging antibiotic resistance in Salmonella presents future therapeutic challenges for clinicians.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota.

Gut·2010
Same author

Pilot study of phoP/phoQ-deleted Salmonella enterica serovar typhimurium expressing Helicobacter pylori urease in adult volunteers.

Infection and immunity·2000
Same author

Safety and immunogenicity of phoP/phoQ-deleted Salmonella typhi expressing Helicobacter pylori urease in adult volunteers.

Vaccine·1999
Same author

Regulation of host immune responses by modification of Salmonella virulence genes.

Nature medicine·1998
Same author

Central nervous system infection with Listeria monocytogenes. 33 years' experience at a general hospital and review of 776 episodes from the literature.

Medicine·1998
Same author

Transcriptional regulation of Salmonella virulence: a PhoQ periplasmic domain mutation results in increased net phosphotransfer to PhoP.

Journal of bacteriology·1996
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Foodborne Pathogens

Background:

  • Nontyphoidal Salmonella are significant foodborne pathogens causing gastroenteritis and systemic infections.
  • Immunocompromised individuals, including those with malignancy, HIV, diabetes, or on immunosuppressive therapy, are at higher risk.
  • Complications include endovascular infections and deep abscesses, posing treatment challenges.

Purpose of the Study:

  • To provide an overview of current problems and emerging trends in nontyphoidal Salmonella infections.
  • To highlight challenges in treating infections in immunocompromised hosts.
  • To address the growing concern of antimicrobial resistance.

Main Methods:

  • Literature review and clinical overview.
  • Analysis of epidemiological trends and clinical manifestations.
  • Discussion of treatment considerations and resistance patterns.

Main Results:

  • Nontyphoidal Salmonella infections are particularly severe in immunocompromised populations.
  • Difficult-to-treat complications such as endovascular infections and abscesses are noted.
  • Emerging resistance to fluoroquinolones and third-generation cephalosporins is a significant concern.

Conclusions:

  • Salmonellosis management requires careful consideration of host immune status and infection site.
  • Antimicrobial resistance in nontyphoidal Salmonella is an increasing threat to effective treatment.
  • Infectious disease clinicians must stay informed about evolving challenges in salmonellosis therapy.

Related Experiment Videos