Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Systemic cidofovir in papillomatosis.

I Van Valckenborgh1, W Wellens, K De Boeck

  • 1Otorhinolaryngology Department, Universitaire Ziekenhuizen Leuven, Leuven, Belgium. isabelle.vanvalckenborgh@med.kuleuven.ac.be

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|February 15, 2001
PubMed
Summary

Systemic cidofovir combined with laser therapy effectively treated severe recurrent respiratory papillomatosis in an 8-year-old, clearing lesions in the upper airways and partially in the lungs without side effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents.

Journal of medicinal chemistry·1992
Same author

Mechanism of anti-human immunodeficiency virus action of polyoxometalates, a class of broad-spectrum antiviral agents.

Molecular pharmacology·1992
Same author

Cell type-specific anti-human immunodeficiency virus type 1 activity of the transactivation inhibitor Ro5-3335.

Antimicrobial agents and chemotherapy·1992
Same author

Activity of different antiviral drug combinations against human cytomegalovirus replication in vitro.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·1992
Same author

3'-C-branched 2'-deoxy-5-methyluridines: synthesis, enzyme inhibition, and antiviral properties.

Journal of medicinal chemistry·1992
Same author

Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives.

Journal of medicinal chemistry·1992

Area of Science:

  • Pediatric Pulmonology
  • Antiviral Therapy
  • Laser Surgery

Background:

  • Recurrent respiratory papillomatosis (RRP) is a rare disease caused by human papillomavirus (HPV).
  • Severe RRP can lead to extensive lesions and pulmonary spread, posing significant treatment challenges.
  • Current treatments often involve repeated surgical debridement, which can be associated with morbidity.

Observation:

  • An 8-year-old patient presented with severe RRP and pulmonary involvement.
  • The patient received systemic cidofovir in conjunction with laser treatment for tracheal lesions.
  • Treatment was administered systemically, representing a novel approach for RRP.

Findings:

  • Complete resolution of papillomatous lesions was observed in the pharynx and larynx.

Related Experiment Videos

  • Significant, though incomplete, regression of lesions occurred in the bronchi and lung parenchyma.
  • No adverse or deleterious side effects were noted during the treatment course.

    • Implications:

    • Systemic cidofovir may represent a viable therapeutic option for severe RRP, particularly with pulmonary spread.
    • This case highlights the potential of combining antiviral therapy with local treatments like laser surgery for RRP.
    • Further research is warranted to evaluate the efficacy and safety of systemic cidofovir in a larger RRP patient cohort.