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[Myocardial SPET in hypertrophic cardiomyopathy]

G Romero-Farina1, J Candell-Riera, O Pereztol-Valdés

  • 1Servicio de Cardiología, Hospital Universitari Vall d'Hebron, Barcelona.

Revista Espanola De Cardiologia
|February 15, 2001
PubMed

Insights

Myocardial perfusion defects are common in hypertrophic cardiomyopathy (HC) patients, but SPECT accuracy for diagnosing coronary artery disease in HC is low, limiting its clinical utility.

Area of Science:

  • Cardiology
  • Nuclear Medicine

Background:

  • Hypertrophic cardiomyopathy (HC) is a complex cardiac condition.
  • Assessing co-existing coronary artery disease (CAD) in HC is clinically important.

Purpose of the Study:

  • To evaluate the diagnostic accuracy of myocardial Single-Photon Emission Computed Tomography (SPET) for detecting coronary artery disease in patients with hypertrophic cardiomyopathy.

Main Methods:

  • 106 patients with echocardiographic HC underwent exercise-rest myocardial SPET using 99mTc-tetrofosmin.
  • Coronary angiography was performed in 31 patients.

Main Results:

  • Myocardial perfusion defects were observed in 35% of HC patients.
  • Only 26% of catheterized patients had significant coronary artery disease.
  • SPET demonstrated low diagnostic accuracy for CAD in this cohort (Sensitivity 50%, Specificity 65%).

Conclusions:

  • Myocardial perfusion defects are frequent in medically treated HC patients.
  • Coronary artery disease is uncommon in HC patients, even those with chest pain.
  • The diagnostic value of SPET for CAD in HC is limited.
Abstract

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