Related Experiment Video
Updated: Jul 24, 2026

07:01
Direct Mouse Trauma/Burn Model of Heterotopic Ossification
Published on: August 6, 2015
[Periarticular heterotopic ossification secondary to central neurogenic dysfunction]
G Ruiz Hernández1, M F Mínguez Rey, F Gomar Sancho
1Servicios de: Urgencias Médicas, Hospital Clínico Universitario, Valencia.
Revista Espanola De Medicina Nuclear
|February 15, 2001
Summary
This case report highlights rare knee involvement in periarticular ossification following cerebral dysfunction. Bone scintigraphy aided in differentiating this from common osteoarthritis, emphasizing diagnostic imaging
Area of Science:
- Medical imaging
- Nuclear medicine
- Orthopedics
Background:
- A 48-year-old woman with tetraparesis post-right lobectomy developed periarticular ossification affecting both knees.
- Periarticular ossification, particularly involving the knee, is uncommon following cerebral dysfunction.
Purpose of the Study:
- To present a rare case of knee involvement in periarticular ossification.
- To discuss the diagnostic challenges and imaging modalities for differentiating heterotopic ossification from osteoarthritis.
Main Methods:
- Bone scintigraphy was utilized to assess the metabolic activity of bone lesions in the knee joints.
- Review of diagnostic imaging methods for periarticular ossification and differential scintigraphic diagnosis.
Main Results:
- Scintigraphy revealed significant involvement of medial and lateral left knee and medial right knee compartments.
- Findings were initially misattributed to degenerative osteoarthritis, underscoring potential diagnostic pitfalls.
Conclusions:
- This case underscores the rarity of knee periarticular ossification secondary to cerebral dysfunction.
- Accurate diagnosis relies on careful interpretation of imaging, distinguishing heterotopic ossification from osteoarthritis.
Related Concept Videos
Blood and Nerve Supply to the Bones
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Disorders of the Skeletal Muscle
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Spinal Cord Injury ll: Pathophysiology
Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
Degenerative Disc Disease ll: Pathophysiology
The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
Secondary Spinal Cord Injury llI: Pathophysiology
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...

