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Benign mediastinal lymphadenopathy in congestive heart failure
1Department of Pneumology, INSERM EMI-U 00-10, CHU Betonneau, Tours, France.
Insights
Benign mediastinal lymphadenopathy can be a sign of severe heart failure. Prompt diagnosis and treatment of congestive heart failure led to the resolution of enlarged lymph nodes in these patients.
Area of Science:
- Cardiology
- Radiology
- Pathology
Background:
- Mediastinal lymphadenopathy can present as an incidental finding on chest radiography.
- Severe coronary heart disease and acute cardiac decompensation were noted in affected patients.
Observation:
- Chest CT revealed multiple enlarged mediastinal lymph nodes (10-17 mm).
- Histopathology showed noninflammatory, benign lesions without structural node compromise.
- One patient experienced lymph node resolution after heart failure treatment.
Findings:
- Benign mediastinal lymphadenopathy is associated with left heart disease and pulmonary edema.
- Radiologic regression on follow-up CT is a key diagnostic indicator.
Implications:
- This association highlights a specific nosology linking heart failure and mediastinal lymphadenopathy.
- Diagnostic approach should consider congestive heart failure as the cause of lymphadenopathy, guiding therapy and follow-up.
Abstract:
We report three cases of benign mediastinal lymphadenopathy revealed by chest radiography in patients ranging in age from 61 to 75 years. All three patients had severe coronary heart disease and a history of several episodes of acute cardiac decompensation. Chest CT scanning contributed to the diagnosis by revealing the existence of multiple enlarged lymph nodes, mostly 10 to 17 mm in short-axis diameter. CT scanning also confirmed the disappearance of the mediastinal lymph nodes in one patient on follow-up after treatment with diuretics and digitalis. Histopathology investigations of biopsy samples obtained by mediastinoscopy consistently revealed noninflammatory, benign lesions that did not affect the node structure. Our report draws attention to the particular nosology of left heart disease represented by benign enlarged lymph nodes of the mediastinum and pulmonary edema. The diagnostic approach to such lymphadenopathy should be guided by the radiologic regression seen on follow-up CT scanning while the patient was undergoing appropriate therapy for congestive heart failure, which constitutes a decisive argument for the congestive heart failure origin.