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Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
Qt dispersion has no prognostic information for patients with advanced congestive heart failure and reduced left
1Copenhagen University Hospital, Gentofte, Denmark.
Insights
QT dispersion does not predict mortality in patients with advanced congestive heart failure (CHF). This study found no link between QT dispersion and all-cause, cardiac, or arrhythmic death in CHF patients.
Area of Science:
- Cardiology
- Electrophysiology
- Heart Failure Research
Background:
- QT dispersion is a potential prognostic marker for tachyarrhythmic events and mortality.
- Its prognostic value in patients with congestive heart failure (CHF) remains unclear.
Purpose of the Study:
- To investigate the prognostic value of QT dispersion in patients with advanced CHF and left ventricular dysfunction.
Main Methods:
- Analysis of baseline ECGs from 703 patients with advanced CHF in the Diamond-CHF study.
- Median follow-up of 18 months, assessing all-cause, cardiac, and cardiac arrhythmic mortality.
- Survival analysis to determine the prognostic information derived from QT dispersion.
Main Results:
- Median QT dispersion was 70 ms, with no significant difference between survivors and nonsurvivors.
- QT dispersion did not show prognostic value for all-cause mortality (P=0.74).
- QT dispersion did not predict cardiac mortality (P=0.55) or cardiac arrhythmic mortality (P=0.38).
Conclusions:
- QT dispersion lacks prognostic value for mortality outcomes in patients with advanced CHF and reduced left ventricular systolic function.
Background:
QT dispersion is a potential prognostic marker of tachyarrhythmic events and death, but it is unclear whether this applies to patients with congestive heart failure (CHF).
Methods And Results:
Of the 1518 patients with advanced CHF and left ventricular dysfunction enrolled in the Danish Investigations of Arrhythmia and Mortality on Dofetilide-CHF (Diamond-CHF) study, a baseline ECG was available in 1319 patients. Of these, QT dispersion could be measured in 703 patients. During a median follow-up of 18 months (minimum 1 year), 285 patients (41%) died. The median QT dispersion was 70 ms (34/155 ms [5%/95% percentiles]), with no difference between survivors and nonsurvivors. Survival analysis revealed no prognostic information derived from QT dispersion regarding all-cause mortality (risk ratio 1.00, 95% CI 1.00 to 1.00; P=0.74), cardiac mortality (risk ratio 1.00, 95% CI 1.00 to 1.01; P=0.55), or cardiac arrhythmic mortality (risk ratio 1.00, 95% CI 0.99 to 1.01; P=0.38).
Conclusions:
QT dispersion has no prognostic value regarding all-cause mortality, cardiac mortality, or cardiac arrhythmic mortality for patients with advanced CHF and reduced left ventricular systolic function.
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