Qt dispersion has no prognostic information for patients with advanced congestive heart failure and reduced left

B Brendorp1, H Elming, L Jun

  • 1Copenhagen University Hospital, Gentofte, Denmark.

Circulation
|February 15, 2001
PubMed

Insights

QT dispersion does not predict mortality in patients with advanced congestive heart failure (CHF). This study found no link between QT dispersion and all-cause, cardiac, or arrhythmic death in CHF patients.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Heart Failure Research

Background:

  • QT dispersion is a potential prognostic marker for tachyarrhythmic events and mortality.
  • Its prognostic value in patients with congestive heart failure (CHF) remains unclear.

Purpose of the Study:

  • To investigate the prognostic value of QT dispersion in patients with advanced CHF and left ventricular dysfunction.

Main Methods:

  • Analysis of baseline ECGs from 703 patients with advanced CHF in the Diamond-CHF study.
  • Median follow-up of 18 months, assessing all-cause, cardiac, and cardiac arrhythmic mortality.
  • Survival analysis to determine the prognostic information derived from QT dispersion.

Main Results:

  • Median QT dispersion was 70 ms, with no significant difference between survivors and nonsurvivors.
  • QT dispersion did not show prognostic value for all-cause mortality (P=0.74).
  • QT dispersion did not predict cardiac mortality (P=0.55) or cardiac arrhythmic mortality (P=0.38).

Conclusions:

  • QT dispersion lacks prognostic value for mortality outcomes in patients with advanced CHF and reduced left ventricular systolic function.
Abstract

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