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Clinical trials in HIV-associated cognitive impairment: cognitive and functional outcomes
G Schifitto1, K Kieburtz, M P McDermott
1Department of Neurology, University of Rochester, NY, USA.
Neurology
|February 15, 2001
Abstract:
Cognitive and functional outcomes are of primary interest in the design of efficacy trials in HIV-associated cognitive impairment. In a longitudinal cohort study, weak associations were found between measures of cognitive performance and commonly used measures of daily functioning (mostly self-report measures) in HIV-infected individuals. Modifications of current functional scales or new functional instruments are needed to assess the clinical relevance of cognitive changes in clinical trials of HIV-associated cognitive impairment.