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Updated: Aug 28, 2026
Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
Published on: December 5, 2015
Histologic architecture and vascularization of hysteroscopically excised intrauterine septa
V Sparac1, S Kupesic, M Ilijas
1Department of Obstetrics and Gynecology, Sveti Duh Hospital, Sveti Duh 64, 10000 Zagreb, Croatia.
Study Objective:
To investigate histologic structures of intrauterine septa resected hysteroscopically.
Design:
Prospective, consecutive study (Canadian Task Force classification II-2).
Setting:
University-affiliated hospital.
Patients:
Seventy-six women evaluated for uterine septa and infertility.
Interventions:
All patients with diagnosis of uterine septum detected by transvaginal color Doppler (TVCD) underwent operative hysteroscopy in which the most prominent part of the septum was encircled with a hysteroscopic loop electrode and removed. Specimens were sent for histopathologic evaluation. The rest of the septum was divided by monopolar needle electrode until the uterine cavity assumed a globular shape.
Measurements And Main Results:
In 63 women (82.8%) preoperative TVCD revealed septal vascularity typical for radial arteries with mean resistance flow of 0.64 +/- 0.06, and enlarged sunusoidal and capillary spaces. Histopathologic results revealed fibromuscular tissue with moderately more connective tissue in 55 cases (72.3%) and myometrial tissue in 21 (27.6%). There was no statistically significant difference (p >0.05) in frequency of septa between patients with primary and secondary infertility.
Conclusion:
Intrauterine septa consisted of the same type of tissue as normal myometrium, with many muscular fibers. We suspect that muscular tissue within the uterine septum is a potential cause of irregular contractility and consequently increased abortion rate in these patients. (J Am Assoc Gynecol Laparosc 8(1):111-116, 2001)
