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Cyclin E immunoexpression in breast ductal carcinoma: pathologic correlations and prognostic implications
R Donnellan1, I Kleinschmidt, R Chetty
1Department of Pathology, Nelson R. Mandela School of Medicine, University of Natal, Durban, South Africa.
Human Pathology
|February 15, 2001
Summary
Cyclin E abnormalities are common in cancer. In South African women, cyclin E in breast cancer correlates with negative estrogen receptor status and high grade, but lacks prognostic significance in multivariate analysis.
Area of Science:
- Oncology
- Cell Biology
- Cancer Research
Background:
- Cell cycle abnormalities are hallmarks of all neoplasms.
- Cyclin E is crucial for the G1/S phase transition and implicated in various cancers.
Purpose of the Study:
- To investigate the role of cyclin E in invasive breast ductal carcinomas.
- To correlate cyclin E expression with prognostic factors in South African women.
Main Methods:
- Immunohistochemical staining for cyclin E was performed on 157 breast cancer specimens.
- Results were compared with clinicopathologic factors: lymph node metastases, tumor size, estrogen receptor status, and histologic grade.
Main Results:
- Positive nuclear cyclin E immunostaining showed a strong correlation with negative estrogen receptor status.
- Cyclin E expression was also associated with high histologic grade.
- Univariate analysis indicated cyclin E staining is linked to poor prognosis.
Conclusions:
- Cyclin E expression in invasive breast ductal carcinoma is associated with specific clinicopathologic features.
- Despite univariate associations, cyclin E does not retain prognostic significance in multivariate analysis for this cohort.