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[Study on the mode of inheritance for familial polycystic ovary syndrome]
1Department of Obstetrics and Gynecology, the Third School of Clinical Medicine, Beijing Medical University, Beijing, 100083 P.R. China. wenweimao@yahoo.com
Objective:
To investigate the mode of inheritance of polycystic ovary syndrome(PCOS).
Methods:
The first female relatives with irregular cycle and the first male relatives with premature balding in each nuclear family were designated the affected. Their prevalence rates in families were respectively calculated. Analyses of segregation ratio were carried out among 139 nuclear families with PCOS by the methods of simple segregation and complex segregation of genetic epidemiology, respectively.
Results:
The prevalence rates of irregular cycle among mothers and sisters with PCOS were 37.4% and 33.1% respectively, and the prevalence rates of premature balding among fathers and brothers of patients were 19.4% and 6.5%, respectively. The simple segregation analysis indicated that the segregation ratio of PCOS trait in siblings was 0.3023, the complex segregation analysis indicated that it fitted in with the inheritance model of co-dominant disorder with full penetrance and sporadic cases. The frequency of homozygote of disease gene in population was 0.046.
Conclusion:
PCOS presents the mode of co-dominant inheritance with complete penetrance.