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Updated: Oct 9, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Biologic properties of non-antibiotic, chemically modified tetracyclines (CMTs): a structured, annotated bibliography
1Division of Rheumatology, Long Island Jewish Medical Center,New Hyde Park, NY 11042, USA. rgreen@lij.edu
Abstract:
The first paper reporting on a potentially important medical property of a non-antimicrobial tetracycline appeared in 1987. Since then, a literature of over 75 papers has supported the therapeutic potential of this class of compounds. In this review, this literature is grouped and organized with commentary on the data which has been published to date. The biomedical applicability of these discoveries obviously covers a wide range of medical conditions and clearly justifies their continued development.
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