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Carisoprodol-related death in a child
Journal of Forensic Sciences
|January 1, 1975
Insights
A child died after ingesting carisoprodol. The primary metabolite found in the child
Area of Science:
- Toxicology
- Pharmacology
- Pediatric Medicine
Background:
- Carisoprodol is a muscle relaxant.
- Meprobamate is a metabolite of carisoprodol.
- Carisoprodol overdose can lead to severe outcomes.
Purpose of the Study:
- To report a fatal carisoprodol overdose in a child.
- To identify the principal metabolite of carisoprodol in a fatal case.
Main Methods:
- Gas chromatography (GC) analysis was performed on biological samples.
- Serum, urine, and gastric contents were analyzed.
Main Results:
- A child ingested approximately 3500 mg of carisoprodol.
- The child experienced gradual deterioration and died within 36 hours.
- GC analysis confirmed meprobamate as the principal carisoprodol metabolite.
Conclusions:
- Carisoprodol overdose can be fatal in children.
- Meprobamate is the primary metabolite responsible for carisoprodol toxicity.
Abstract:
A child who ingested approximately 3500 mg of carisoprodol gradually deteriorated and died within 36 h. GC analysis of serum, urine, and gastric samples indicated that meprobamate was the principal metabolite of carisoprodol.