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Herniated blastomere following chemically assisted hatching may result in monozygotic twins
1Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Taipei Medical College Hospital, #252, Wu Hsing Street, Taipei 110, Taiwan.
Objective:
To explore a possible mechanism of the increasing incidence of monozygotic twins following assisted hatching of human embryos.
Design:
Case report.
Setting:
Clinical research center in a medical school teaching hospital.
Patient:
A 37-year-old infertile woman with repeated IVF failures.
Intervention(S):
Assisted hatching of the day 3 embryos using acidic Tyrode's solution.
Main Outcome Measure(S):
The morphology of the zona-drilled embryos and the pregnancy outcome.
Result(S):
After assisted hatching, a herniated blastomere through an oversized opening in the zona pellucida was found in one embryo. The transfer of two zona-drilled embryos resulted in a triplet pregnancy.
Conclusion(S):
Large openings in the zona pellucida following chemically assisted hatching may cause premature hatching of the blastomeres and may be implicated in the occurrence of monozygotic twins.