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Bordetella pertussis, molecular pathogenesis under multiple aspects.

C Locht1, R Antoine, F Jacob-Dubuisson

  • 1INSERM U447, Institut Pasteur de Lille, 1 rue du Prof. Calmette, F-59019, Lille Cedex, France. camille.locht@pasteur-lille.fr

Current Opinion in Microbiology
|February 15, 2001
PubMed
Summary

Bordetella pertussis utilizes numerous virulence factors beyond toxins, with most controlled by the BvgAS regulon. However, iron uptake systems are largely independent, highlighting complex regulation in pertussis pathogenesis.

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Area of Science:

  • Microbiology
  • Genomics
  • Bacterial Pathogenesis

Background:

  • Bordetella pertussis is a significant human pathogen responsible for whooping cough.
  • Virulence factor expression is crucial for B. pertussis pathogenesis.
  • Genomic studies reveal a complex array of virulence determinants.

Purpose of the Study:

  • To investigate the regulatory mechanisms governing Bordetella pertussis virulence factors.
  • To differentiate between BvgAS-dependent and independent virulence determinants.
  • To explore the role of iron regulation in B. pertussis virulence.

Main Methods:

  • Genomic analysis of B. pertussis virulence genes.
  • Investigation of the BvgAS regulon.
  • Analysis of iron-regulated gene expression.

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Main Results:

  • B. pertussis employs numerous virulence factors beyond known toxins and adhesins.
  • Most identified virulence factors are regulated by the BvgAS two-component system.
  • Iron uptake systems, including siderophore receptors, represent key BvgAS-independent virulence determinants, primarily regulated by iron availability.

Conclusions:

  • Bordetella pertussis pathogenesis involves a sophisticated regulatory network.
  • The BvgAS regulon controls a broad spectrum of virulence factors.
  • Iron acquisition mechanisms are critical and operate independently of the BvgAS system, offering potential targets for therapeutic intervention.