Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Supraspinal interactions resulting from experimental dorsal column stimulation.

H Bantli, J R Bloedel, P Thienprasit

    Journal of Neurosurgery
    |March 1, 1975
    PubMed
    Summary

    Dorsal column stimulation in rhesus monkeys altered supraspinal responses, indicating its mechanism may not rely on dorsal horn interactions. This finding is crucial for understanding spinal cord stimulation efficacy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The cerebellum and eye-blink conditioning: learning versus network performance hypotheses.

    Neuroscience·2009
    Same author

    Inferior olivary inactivation abolishes conditioned eyeblinks: extinction or cerebellar malfunction?

    Behavioural brain research·2007
    Same author

    Control of aperture closure during reach-to-grasp movements in Parkinson's disease.

    Experimental brain research·2005
    Same author

    Glutamate neurotransmission in the cerebellar interposed nuclei: involvement in classically conditioned eyeblinks and neuronal activity.

    Journal of neurophysiology·2004
    Same author

    Adaptation of reach-to-grasp movement in response to force perturbations.

    Experimental brain research·2003
    Same author

    Carlo, the cerebellum, and me.

    Archives italiennes de biologie·2002

    Area of Science:

    • Neuroscience
    • Spinal Cord Physiology

    Background:

    • Clinical dorsal column stimulation is used for pain management.
    • The precise neural mechanisms underlying its efficacy are not fully understood.
    • Previous hypotheses suggested dorsal horn interactions were critical.

    Purpose of the Study:

    • To investigate if dorsal column stimulation affects responses in supraspinal nuclei via ventral spinal cord pathways.
    • To test the hypothesis that dorsal column stimulation's effects are independent of dorsal horn interactions.

    Main Methods:

    • Experiments were conducted on rhesus monkeys.
    • Dorsal column electrodes, similar to those used clinically, were implanted.
    • Responses evoked in supraspinal nuclei were measured following stimulation.

    Related Experiment Videos

    Main Results:

    • Dorsal column stimulation induced significant changes in evoked responses within supraspinal nuclei.
    • The observed effects could not be attributed to a conduction block in ascending spinal pathways.
    • This suggests an alternative mechanism of action for dorsal column stimulation.

    Conclusions:

    • The findings challenge the necessity of dorsal horn interactions for the efficacy of dorsal column stimulation.
    • The results imply that supraspinal modulation may be a key mechanism.
    • This research provides new insights into the neurophysiological basis of spinal cord stimulation.