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Updated: Jul 11, 2026

Scale-Up of Mammalian Cell Culture using a New Multilayered Flask
08:39

Scale-Up of Mammalian Cell Culture using a New Multilayered Flask

Published on: December 5, 2011

Scale-up of filamentous organisms from tubes and shake-flasks into stirred vessels

W Katzer1, M Blackburn, K Charman

  • 1TerraGen Discovery (UK) Ltd., Slough, UK

Biochemical Engineering Journal
|February 15, 2001
PubMed

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Scale-Up Processes01:14

Scale-Up Processes

The scale-up of microbial fermentation processes is essential in industrial biotechnology, allowing the transition from laboratory-scale experiments to commercial-scale production while aiming to maintain product yield and quality. This process requires meticulous adjustment of equipment design, process parameters, and contamination control strategies to accommodate increasing culture volumes.At the laboratory scale, cultures are typically maintained in 1 to 10-liter glass or autoclavable...