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Updated: Aug 2, 2026

Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities
Published on: May 27, 2015
1-Methylindole-3-carboxaldehyde oxime derivatives
R W Janes1, B S Potter, M A Naylor
1School of Biological Sciences, Queen Mary and Westfield College, University of London, Mile End Road, London E1 4NS, England. r.w.janes@qmw.ac.uk
Abstract:
1-Methylindole-3-carboxaldehyde oxime, C10H10N2O, (I), and (E)-5-methoxy-1-methylindole-3-carboxaldehyde oxime, C11H12N2O2, (II), were examined structurally to ascertain the geometry of the hydroxyimino function relative to the indole core. Oxime (I) exhibits cis geometry and there are two molecules in the asymmetric unit. In contrast, oxime (II) exhibits trans geometry and has four molecules in the asymmetric unit, with the geometry of the 5-methoxy group in one molecule differing from that in the other three. Both crystal structures are maintained by hydrogen bonding with no pi-stacking of the indole moiety present.
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