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A Strategy for Sensitive, Large Scale Quantitative Metabolomics
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p-Formamidobenzoic acid.

H Novoa De Armas1, O M Peeters, N M Blaton

  • 1Laboratorium voor Analytische Chemie en Medicinale Fysicochemie, Faculteit Farmaceutische Wetenschappen, Katholieke Universiteit Leuven, Van Evenstraat 4, B-3000 Leuven, Belgium. hector.novoa@farm.kuleuven.ac.be

Acta Crystallographica. Section C, Crystal Structure Communications
|February 15, 2001
PubMed
Summary
This summary is machine-generated.

This study details an aromatic amide, C8H7NO3, which forms a significant hydrogen-bond network in its crystal structure. These crystals emerged during the synthesis of acridones using benzoic acid derivatives.

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Area of Science:

  • Crystallography
  • Organic Chemistry
  • Materials Science

Background:

  • Aromatic amides are crucial in organic synthesis and materials science.
  • Benzoic acid derivatives serve as key intermediates in synthesizing complex organic molecules.
  • Understanding crystal structures informs molecular design and property prediction.

Purpose of the Study:

  • To characterize the crystal structure of a novel aromatic amide (C8H7NO3).
  • To investigate the intermolecular interactions, specifically hydrogen bonding, within the crystal lattice.
  • To report the context of its formation during acridone synthesis.

Main Methods:

  • Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
  • Chemical synthesis involving benzoic acid derivatives was performed.
  • Crystallization techniques were utilized to obtain suitable single crystals.

Main Results:

  • The title compound, C8H7NO3, an aromatic amide, was synthesized and structurally characterized.
  • An extensive three-dimensional hydrogen-bond network was identified within the crystal structure.
  • The compound was serendipitously obtained as an intermediate in the synthesis of acridones.

Conclusions:

  • The crystal structure of C8H7NO3 reveals significant hydrogen bonding, influencing its solid-state properties.
  • The formation of this amide highlights a potential synthetic route or byproduct in acridone preparation.
  • Further studies can explore the properties and applications of this hydrogen-bonded aromatic amide.