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Related Experiment Videos

3-(1-Chlorovinyl)-2,4,6-trimethoxybenzaldehyde.

A K Panda1, M R Parthasarathy, W Errington

  • 1Department of Chemistry, University of Delhi, Delhi 110 007, India.

Acta Crystallographica. Section C, Crystal Structure Communications
|February 15, 2001
PubMed
Summary

Researchers synthesized a novel compound using the Vilsmeier-Haack reaction. Structural analysis revealed unique substituent twists and one-dimensional chains formed by intermolecular hydrogen bonding.

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Area of Science:

  • Organic Chemistry
  • Crystallography

Background:

  • Phloroacetophenone is a key starting material in organic synthesis.
  • The Vilsmeier-Haack reaction is a versatile method for formylation and chlorination.

Purpose of the Study:

  • To synthesize and characterize a novel compound derived from phloroacetophenone.
  • To investigate the structural and conformational properties of the synthesized molecule.

Main Methods:

  • Synthesis via the Vilsmeier-Haack reaction.
  • X-ray crystallography for structural determination.
  • Analysis of intermolecular interactions.

Main Results:

  • Successful synthesis of the title compound (C12H13ClO4).
  • Observed significant twisting (approx. 75 degrees) of chlorovinyl and methoxy groups relative to the aromatic plane.

Related Experiment Videos

  • Identified one-dimensional chains formed by C-H...O intermolecular hydrogen bonding along the a-axis.

    • Conclusions:

    • The Vilsmeier-Haack reaction provides an effective route to this novel substituted compound.
    • The molecule exhibits distinct conformational features with specific substituent orientations.
    • Intermolecular hydrogen bonding plays a crucial role in the solid-state structure, leading to chain formation.