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Ovariectomy and 17β-estradiol Replacement in Rats and Mice: A Visual Demonstration
Published on: June 7, 2012
Effects of progesterone on the elevation of tail skin temperature in ovariectomized rats
T Kobayashi1, M Tamura, M Hayashi
1Pharmacological Research Department, Teijin Institute for Bio-Medical Research, Hino, 191-8512 Japan. ts.kobayashi@teijin.co.jp
The Japanese Journal of Physiology
|February 15, 2001
Abstract:
We examined the effects of progesterone on the elevation of tail skin temperature (TST) in ovariectomized rats and compared them with those of estradiol. Progesterone showed only insignificant effects on the TST elevation, whereas estradiol showed complete inhibition. The TST elevation induced by ovariectomy is caused by estradiol deficiency, but progesterone plays little or no role.
