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Related Experiment Videos

Forearm vasoreactivity in type 1diabetic subjects.

J D Allen1, M Welsch, N Aucoin

  • 1Department of Kinesiology, Louisiana State University, Baton Rouge, Louisiana 70803, USA.

Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquee
|February 15, 2001
PubMed
Summary

Type I diabetes does not impair forearm blood flow vasoreactivity. Healthy individuals and diabetic subjects showed similar blood flow responses to stimuli, indicating preserved vasodilatory capacity in diabetes without other risk factors.

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Area of Science:

  • Cardiovascular Physiology
  • Endocrinology

Background:

  • Type I diabetes is associated with endothelial dysfunction.
  • Cardiovascular risk factors are common in diabetic populations.

Purpose of the Study:

  • To compare forearm vasoreactivity in Type I diabetic subjects and healthy controls.
  • To investigate if Type I diabetes, in the absence of other cardiovascular risk factors, affects vasodilatory capacity.

Main Methods:

  • Strain gauge plethysmography was used to measure forearm blood flow.
  • Vasoreactivity was assessed at rest, after arterial occlusion (OCC), and after occlusion with handgrip exercise (ROCC).
  • Participants were matched for age and exercise capacity.

Main Results:

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  • Forearm blood flow increased significantly with stimuli in both groups.
  • No significant differences in forearm blood flow were observed between Type I diabetic subjects and healthy controls under any condition.
  • These findings suggest blood flow is stimulus-dependent.

    • Conclusions:

    • Type I diabetes, when isolated from other cardiovascular risk factors, does not appear to impair forearm vasodilatory capacity.
    • Preserved vasoreactivity suggests endothelial function may be maintained in early or uncomplicated Type I diabetes.