Related Experiment Videos
TSPY variants in six loci on the human Y chromosome
F Dechend1, G Williams, B Skawran
1Institut für Humangenetik, Medizinische Hochschule, Hannover, Germany.
Cytogenetics and Cell Genetics
|February 15, 2001
Abstract:
We have studied the structure, organization, and evolution of the human TSPY gene family by mapping three sequence variants identified through RT-PCR analysis onto genomic clones derived from two different YAC contigs. TSPY gene family members occur in at least six locations on the human Y chromosome, and each cluster contains a unique combination of variants. Our data further suggest that an 18-bp tandem duplication found in TSPY exon 1 originated from an unequal sister chromatid exchange between two tandemly arranged TSPY clusters.