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Published on: June 30, 2023
Nicorandil can induce severe oral ulceration
C Scully1, A M Azul, A Crighton
1Department of Oral Medicine, Eastman Dental Institute of Oral Health Care Sciences, University College London, England. CScully@eastman.ucl.ac.uk
Objective:
To increase physicians' and dentists' awareness that nicorandil is a potential inducer of severe mouth ulceration.
Study Design:
Nine new cases of ulceration from 3 European countries were included in this study.
Results:
Oral ulceration developed within 9 months of beginning nicorandil therapy, and ulcers resolved within 1 month of withdrawal of the drug. No lesions developed on other epithelia.
Conclusions:
A number of drugs used in the care of patients with cardiovascular disease can cause oral adverse effects. Nicorandil, a new potassium-channel activator used in some countries to treat angina pectoris, precipitates persistent ulcerative stomatitis in some patients.
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