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Updated: Jul 30, 2026

Targeting the Rat's Small Bowel: Long-Term Infusion into the Superior Mesenteric Artery
Published on: April 8, 2021
Distal thoracic aorta as inflow for the treatment of chronic mesenteric ischemia
M A Farber1, R E Carlin, W A Marston
1Division of Vascular Surgery, University of North Carolina, Chapel Hill, NC 27599-7212, USA. Mark_Farber@med.unc.edu
Insights
Surgical repair of chronic mesenteric ischemia using the distal thoracic aorta for inflow offers excellent long-term patency and survival. This antegrade bypass grafting technique demonstrates low complication rates, making it a viable primary treatment option.
Area of Science:
- Vascular Surgery
- Gastrointestinal Surgery
- Surgical Outcomes
Background:
- Chronic mesenteric ischemia (CMI) treatment traditionally uses abdominal aorta inflow for bypass grafts.
- The distal thoracic aorta (DTA) presents a potential alternative inflow source for mesenteric revascularization.
- Evaluating DTA inflow for CMI surgical treatment is crucial for optimizing patient outcomes.
Purpose of the Study:
- To assess the efficacy and safety of using the distal thoracic aorta (DTA) as an inflow source for mesenteric revascularization in patients with chronic mesenteric ischemia (CMI).
Main Methods:
- A retrospective review of patients who underwent mesenteric revascularization for CMI using DTA inflow between 1990 and 1999.
- Utilized a thoracoretroperitoneal incision for surgical exposure and a partial occlusion clamp for maintaining distal aortic flow.
- Grafts were placed to the celiac and/or superior mesenteric arteries.
Main Results:
- Eighteen patients with CMI underwent DTA-inflow mesenteric bypass grafting.
- Perioperative mortality was 6% (1 patient), with 17% experiencing major complications; no kidney failure, mesenteric infarction, or spinal cord ischemia occurred.
- Midterm results showed 100% graft patency, 76% 5-year survival, and complete symptom resolution in all patients.
Conclusions:
- Antegrade mesenteric revascularization utilizing DTA inflow is a safe and effective procedure for CMI.
- This approach is associated with low morbidity, mortality, and excellent midterm graft patency and patient survival.
- DTA inflow should be considered a primary surgical option for mesenteric revascularization in CMI patients.
Purpose:
Mesenteric revascularization for chronic mesenteric ischemia (CMI) traditionally involves antegrade or retrograde bypass graft originating from the supraceliac or infrarenal aorta. The distal thoracic aorta (DTA) may provide a better inflow source than the abdominal aorta. The purpose of this study was to evaluate the results with the DTA used as inflow for the surgical treatment of CMI.
Methods:
All patients undergoing mesenteric revascularization for CMI with grafts originating from the DTA were identified from 1990 to 1999. A ninth interspace thoracoretroperitoneal incision was used for exposure, and distal aortic flow was maintained by use of a partial occlusion clamp.
Results:
Eighteen consecutive patients with CMI underwent mesenteric bypass grafting with the DTA used as inflow. All patients were admitted with chronic abdominal pain or weight loss, with two (12%) requiring urgent revascularization because of acute exacerbation of chronic symptoms. Fourteen (78%) patients had both celiac and superior mesenteric artery bypass grafts placed, and three (17%) patients had superior mesenteric artery grafts alone. There was one (6%) perioperative death and three (17%) major complications. There was no kidney failure, mesenteric infarction, or spinal cord ischemia. The life-table survival rate was 89%, 89%, and 76% at 1, 3, and 5 years, respectively. All 18 patients remained symptom free and required no additional procedures to assist patency. There was no evidence of graft stenosis or occlusion (100% patency) for those grafts evaluated objectively during the mean follow-up of 34.8 months (range, 1-97 months).
Conclusions:
Antegrade mesenteric revascularization with the DTA used as inflow is associated with low morbidity and mortality rates. Furthermore, it provides excellent midterm patency and survival results and should be considered as a primary approach for reconstruction of patients with CMI.
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