Related Experiment Video
Updated: Jul 17, 2026

Transthoracic Echocardiography in Mice
Published on: May 29, 2010
Gender Differences in Mitral Inflow Parameters of Doppler Echocardiography
Ara Sadaniantz1, Betsy J. Hadi, Linda Saint Laurent
1Division of Cardiology, The Miriam Hospital, 164 Summit Avenue, Providence, RI 02906.
Abstract:
BACKGROUND: Doppler echocardiographic parameters are useful in understanding cardiac function. Previous studies have evaluated the physiologic effects of heart rate, body position, and age on left ventricular (LV) Doppler inflow variables. OBJECTIVE: The aim of this study was to investigate the effect of gender on LV Doppler inflow variables. METHODS: A complete echocardiographic study was performed in the left lateral position on 25 male and 25 female normal subjects. The Doppler variables, of E and A wave velocities, acceleration and deceleration times of the E wave velocity, and cardiac chamber dimensions were measured. RESULTS: The aortic root size (3.2 +/- 0.4 vs 2.8 +/- 0.4 cm, P = 0.002), LV end systolic (2.8 +/- 0.3 vs 2.5 +/- 0.5 cm, P = 0.03), and LV end diastolic dimensions (5.0 +/- 0.4 vs 4.5 +/- 0.6 cm, P = 0.003) were larger in men compared to women. E wave deceleration time (233 +/- 40 vs 197 +/- 37 msec, P = 0.002) was longer in men compared to women. Using univariate analysis, deceleration time of the E wave was correlated with heart rate (P = 0.001), maximal A wave velocity (P = 0.007), acceleration time of the E wave (P = 0.01), LV systolic dimension (P = 0.03), maximal E wave velocity (P = 0.04), LV diastolic dimension (P = 0.06), and height (P = 0.07). E/A ratio, body surface area, age, weight, and left atrial dimension had no significant correlation with the deceleration time of the E wave. In the multivariate model, heart rate (P = 0.001) had the most significant (inverse) correlation with deceleration time of the E wave. CONCLUSIONS: In this cohort of subjects, there were significant differences in LV systolic and diastolic measurements and Doppler measurements of deceleration time of the E wave between men and women. The differences in Doppler measurements between men and women are most likely affected by the higher heart rate in women. Therefore, when interpreting deceleration time of the E wave, the effect of heart rate should be considered.
More Related Videos
12:12Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
Published on: February 14, 2017
04:48Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery
Published on: November 28, 2018
Related Concept Videos
Mitral Valve Prolapse I: Introduction
Mitral Regurgitation I: Introduction
Mitral Regurgitation II: Clinical Features and Diagnostic Tests
Mitral Stenosis I: Introduction
Mitral Stenosis II: Clinical features and Diagnostic Tests