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Related Experiment Videos

Left Ventricular Diastolic Function in a Population Sample of Elderly Men.

Bertil Andrén1, Lars Lind, Göran Hedenstierna

  • 1Department of Clinical Physiology, University of Uppsala, Uppsala, Sweden.

Echocardiography (Mount Kisco, N.Y.)
|February 15, 2001
PubMed
Summary

In elderly men, the E/A ratio did not reliably detect diastolic dysfunction in cardiovascular disease. Isovolumic relaxation time (IVRT) showed more promise, but age-related changes complicated interpretation.

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Area of Science:

  • Cardiology
  • Geriatrics
  • Diagnostic Imaging

Background:

  • Echocardiography with Doppler is standard for assessing left ventricular (LV) diastolic function.
  • Physiological aging significantly impacts LV diastolic function, complicating interpretation of Doppler-derived indices.
  • Assessing diastolic function in elderly populations requires careful consideration of age-related changes.

Purpose of the Study:

  • To evaluate the utility of various Doppler-derived indices for assessing LV diastolic function in elderly men.
  • To determine if common indices can differentiate healthy elderly individuals from those with cardiovascular disease.

Main Methods:

  • Analysis of health screening data from 584 men aged 70 years.
  • Assessment of Doppler-derived indices including E/A ratio, isovolumic relaxation time (IVRT), and E wave deceleration time (DT).

Related Experiment Videos

  • Comparison of indices between apparently healthy subjects and those with coronary heart disease (CHD), hypertension, or diabetes mellitus.

    • Main Results:

    • The E/A ratio was reduced in healthy elderly men and did not differentiate them from those with CHD or hypertension.
    • Only subjects with systolic dysfunction showed a significantly decreased E/A ratio.
    • Isovolumic relaxation time (IVRT) was prolonged in subjects with CHD or hypertension, but differences were small.
    • E wave deceleration times (DT) and pulmonary venous blood flow were similar across groups.
    • Left atrial size increased in subjects with cardiovascular disease.

    Conclusions:

    • The E/A ratio is not a reliable indicator of LV diastolic dysfunction in elderly men with cardiovascular disease.
    • Age-associated changes in LV compliance may mask or override the effects of cardiovascular disease on diastolic function indices.
    • Isovolumic relaxation time (IVRT) showed some sensitivity but differences were minimal, suggesting limitations in current Doppler indices for this population.