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Related Experiment Videos

Load-Independent Indices of Left Ventricular Function Using Automated Border Detection.

John Gorcsan

    Echocardiography (Mount Kisco, N.Y.)
    |February 15, 2001
    PubMed
    Summary

    Echocardiographic automated border detection allows assessment of left ventricular (LV) volumes and function independent of loading conditions. This review covers LV pressure-area relations, their clinical applications, and alternative methods for evaluating cardiac performance.

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    Area of Science:

    • Cardiovascular imaging
    • Echocardiography
    • Cardiac physiology

    Background:

    • Automated border detection in echocardiography enables assessment of left ventricular (LV) cross-sectional cavity areas and volumes.
    • This facilitates the use of LV pressure-volume relationships for determining LV function, largely independent of loading conditions.

    Purpose of the Study:

    • To review validation studies of LV cross-sectional area as a surrogate for LV volume in animal models and humans.
    • To discuss clinical applications of LV pressure-area relations.
    • To explore the use of arterial pressure as a substitute for LV ejection pressure and assess right ventricular performance using pressure-area relations.
    • To discuss preload-adjusted maximal power as a load-insensitive method for LV performance assessment.

    Main Methods:

    Related Experiment Videos

    • Review of existing validation studies on echocardiographic automated border detection.
    • Analysis of clinical applications of LV pressure-area relations.
    • Evaluation of the use of arterial pressure and preload-adjusted maximal power in assessing cardiac function.

    Main Results:

    • LV cross-sectional area has been validated as a surrogate for LV volume.
    • LV pressure-area relations provide a load-independent assessment of LV function.
    • Arterial pressure can substitute for LV ejection pressure in pressure-area relation analysis.
    • Pressure-area relations and preload-adjusted maximal power offer alternative methods for evaluating cardiac performance.

    Conclusions:

    • Echocardiographic automated border detection and LV pressure-area relations offer valuable, load-independent methods for assessing cardiac function.
    • These techniques have broad clinical applications for both left and right ventricular performance evaluation.
    • Preload-adjusted maximal power presents a promising alternative for load-insensitive assessment of LV performance.