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Segmental renal hypoplasia and hypertension
The Journal of Urology
|April 1, 1975
Summary
Congenital renal hypoplasia, also known as Ask-Upmark kidney, is linked to hypertension. Surgical removal of the affected kidney cured the hypertension in this case study.
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Pathology
Background:
- Congenital renal hypoplasia, or Ask-Upmark kidney, is a known cause of secondary hypertension.
- The renin-angiotensin-aldosterone system is implicated in the pathophysiology of hypertension associated with renal abnormalities.
Observation:
- A case study is presented detailing the clinical, roentgenographic, and pathological features of Ask-Upmark kidney.
- The patient presented with severe hypertension attributed to the congenital renal anomaly.
Findings:
- Abnormal renin production from the affected kidney was identified.
- This finding supports the involvement of the renin-angiotensin-aldosterone axis in the hypertension's development.
Implications:
- Unilateral nephrectomy (surgical removal of one kidney) effectively cured the hypertension.
- This case highlights the importance of considering congenital renal anomalies in the differential diagnosis of secondary hypertension and the potential curative effect of nephrectomy.