Effects of drugs on two-lever single-alternation performance in rats and mice(2)

The effects of d-amphetamine, chlorpromazine and pentobarbital on single alternation were compared in mice and rats. Chlorpromazine and d-amphetamine produced dose-related decreases in both accuracy and rate of responding with no differences in species sensitivity. Pentobarbital also produced dose-dependent decreases in accuracy and rate of responding in rats and on rate of responding in mice, but accuracy on the single alternation problem in mice was resistant to pentobarbital, even at doses that markedly reduced rate of responding. Higher doses of chlorpromazine, d-amphetamine and pentobarbital were required to produce effects in mice after trimethyltin exposure.