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Published on: March 14, 2017
Synchronous water-clear cell double parathyroid adenomas a hitherto uncharacterized entity?
W I Kuhel1, D Gonzales, S A Hoda
1Department of Otorhinolaryngology, New York Presbyterian Hospital-Weill Medical College of Cornell University, New York, NY 10021, USA.
Archives of Pathology & Laboratory Medicine
|February 15, 2001
Summary
This study reports a rare case of synchronous double parathyroid adenomas composed of water-clear cells, a condition previously undocumented. This finding advances understanding of primary hyperparathyroidism causes.
Area of Science:
- Endocrinology
- Surgical Pathology
Background:
- Water-clear cell hyperplasia is a rare cause of primary hyperparathyroidism.
- Water-clear cell parathyroid adenomas are exceptionally rare, with only two prior cases documented.
Observation:
- This report details a unique patient presenting with synchronous double parathyroid adenomas of the water-clear cell type.
- Enlarged superior parathyroid glands were replaced by water-clear cells, while inferior glands appeared normal on gross examination and biopsy.
Findings:
- The case is most consistent with double adenomas of the water-clear cell type.
- Molecular analysis confirmed monoclonality of both lesions, though asymmetric hyperplasia cannot be entirely excluded.
Implications:
- This case expands the spectrum of rare causes for primary hyperparathyroidism.
- It highlights the importance of thorough pathological examination in diagnosing complex parathyroid conditions.
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