Related Experiment Video

Updated: Aug 7, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

The epidemiological study on the correlation between serum lipids and cerebro-cardiovascular disease

K Sawai, S Shibata, Y Morisawa

    Japanese Circulation Journal
    |March 1, 1975
    PubMed

    Insights

    Controlling high cholesterol and triglycerides is key to preventing cardiovascular and cerebrovascular diseases. These conditions are linked to obesity, hypertension, and abnormal heart and eye exams.

    Area of Science:

    • Cardiology
    • Neurology
    • Metabolic Diseases

    Background:

    • Hyperlipidemia, obesity, and hypertension are prevalent risk factors for cardiovascular and cerebrovascular diseases.
    • Understanding the specific associations between lipid profiles and major adverse cardiovascular events is crucial for effective prevention strategies.

    Purpose of the Study:

    • To investigate the correlations between hyperlipidemia and other cardiovascular risk factors.
    • To determine the relationship between hypertension, hyperlipidemia, and the incidence of cerebrovascular and cardiovascular diseases, including cerebral hemorrhage, cerebral infarction, myocardial infarction, and angina pectoris.

    Main Methods:

    • The study analyzed the correlation between hyperlipidemia and various health indicators such as obesity, hypertension, electrocardiogram (ECG) abnormalities, and eyeground examinations.
    • Statistical associations were examined between hypertension, hypercholesterolemia (hyper-Ch), and hypertriglyceridemia (hyper-TG) with the incidence of cerebral hemorrhage, cerebral infarction, myocardial infarction, and angina pectoris.

    Main Results:

    • Significant correlations were observed between hyperlipidemia and obesity, hypertension, abnormal ECG, and abnormal eyeground.
    • Hypertension was closely associated with cerebral hemorrhage, while hyperlipidemia was not.
    • Hypertension combined with both hypercholesterolemia and hypertriglyceridemia showed a strong relationship with cerebral infarction development.
    • Hypertension with hypercholesterolemia appeared related to the incidence of myocardial infarction and angina pectoris.

    Conclusions:

    • The findings suggest that controlling hypercholesterolemia and hypertriglyceridemia is beneficial for preventing cerebro-cardiovascular diseases.
    • Hypertension is a significant risk factor for cerebral hemorrhage and, in conjunction with lipid abnormalities, for cerebral infarction and potentially other cardiovascular events.

    More Related Videos

    Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles09:15

    Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

    Published on: November 10, 2017

    High-Density Lipoprotein-Specific Phospholipid Efflux Assay07:08

    High-Density Lipoprotein-Specific Phospholipid Efflux Assay

    Published on: September 30, 2025

    Related Concept Videos

    Lipids: Dietary Sources and Requirements01:18

    Lipids: Dietary Sources and Requirements

    Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ meats, shellfish,...
    Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

    Blood Studies for Cardiovascular System I: Cardiac Biomarkers

    Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
    The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
    Troponins
    Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
    Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

    Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

    Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
    These markers indicate stress or strain on the heart muscle:
    Natriuretic Peptides (BNP)
    Cardiac myocytes produce these hormones in response to ventricular stretching...
    Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

    Blood Studies for Cardiovascular System III: Serum Lipid Profile

    Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
    Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
    Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
    Coronary Artery Disease IV: Preventive Measures01:26

    Coronary Artery Disease IV: Preventive Measures

    Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
    Atherosclerosis III: Management01:26

    Atherosclerosis III: Management

    Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...