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Fibrosarcomatous dermatofibrosarcoma protuberans with giant rosettes.
1Sikl's Department of Pathology, Faculty Hospital, Charles University, Pilsen, Czech Republic. zamecnikmichal@hotmail.com
The American Journal of Dermatopathology
|February 15, 2001
Summary
A rare case of dermatofibrosarcoma protuberans (DFSP) showed low-grade fibrosarcoma with giant rosettes in recurrence areas. This suggests a potential link between DFSP fibrosarcoma and hyalinizing spindle cell tumors.
Area of Science:
- Oncology
- Dermatopathology
- Surgical Pathology
Background:
- Dermatofibrosarcoma protuberans (DFSP) is a rare, locally aggressive skin cancer.
- Recurrent DFSP can exhibit diverse histological patterns.
- Giant rosettes are uncommon findings in DFSP.
Observation:
- A rare case of recurrent DFSP presented with areas of low-grade fibrosarcoma containing giant rosettes.
- These giant rosettes mimicked the pattern seen in hyalinizing spindle cell tumor with giant rosettes.
- Gradual transitions were observed between DFSP and fibrosarcomatous components.
Findings:
- Both primary and recurrent DFSP lesions demonstrated diffuse CD34 immunoreactivity.
- The presence of giant rosettes in fibrosarcomatous areas of DFSP was noted.
- Histological features suggested a possible histogenetic link.
Implications:
- This case highlights an unusual presentation of DFSP recurrence.
- The findings suggest a potential relationship between DFSP fibrosarcoma and hyalinizing spindle cell tumor with giant rosettes.
- Further research may clarify the histogenesis of these related entities.