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Acute measles gastric infection
M Vieth1, K Dirshmid, U Oehler
1Institut für Pathologie, Klinikum Bayreuth, Germany. vieth.lkpathol@uni-bayreuth.de
The American Journal of Surgical Pathology
|February 15, 2001
Summary
Measles virus can infect the gastric mucosa, causing a rare condition called morbilliform gastritis. This case highlights measles virus
Area of Science:
- Gastroenterology
- Virology
- Pathology
Background:
- A 44-year-old man presented with abdominal pain, leading to gastroscopy.
- Endoscopic examination revealed inflammatory changes in the gastric antrum and corpus.
- Histological analysis indicated post-antibiotic treatment ex-Helicobacter pylori-gastritis.
Observation:
- Biopsies showed unusual multinucleated giant cells and inclusion bodies in the gastric mucosa.
- These giant cells resembled Warthin-Finkeldey cells, typically seen in measles prodrome.
- Immunohistochemistry confirmed the presence of measles virus antigen within these cells.
Findings:
- The patient was diagnosed with morbilliform gastritis, a previously undescribed condition.
- This diagnosis was based on histological evidence of measles virus infection in the gastric mucosa.
- The findings suggest measles virus replication can affect the stomach.
Implications:
- This case report expands the understanding of measles virus systemic infection.
- It demonstrates that the gastric mucosa is a potential site for measles viral replication.
- The findings emphasize the importance of considering measles in gastritis cases with unusual histological features.