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Related Experiment Videos

The acute phase response and exercise: the ultramarathon as prototype exercise.

K E Fallon1

  • 1Department of Sports Medicine, Australian Institute of Sport, Belconen, Australian Capital Territory, Australia.

Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine
|February 15, 2001
PubMed
Summary

Endurance exercise triggers an acute phase response similar to medical conditions. Six key markers indicated this response in ultramarathon runners, supporting exercise-induced inflammation parallels.

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Area of Science:

  • Exercise physiology
  • Immunology
  • Biochemistry

Background:

  • The acute phase response (APR) is a systemic reaction to tissue injury or inflammation.
  • Controversy exists regarding the nature of the APR following strenuous endurance exercise.
  • Understanding exercise-induced APR is crucial for distinguishing it from pathological inflammation.

Purpose of the Study:

  • To investigate the similarities between the acute phase response following endurance exercise and that seen in general medical/surgical conditions.
  • To analyze serum levels of specific acute phase reactants in ultramarathon runners.

Main Methods:

  • A case series field study involving 8 experienced ultramarathon runners (7 male, 1 female).
  • Participants completed a 6-day track race.

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  • Serum levels of 11 acute phase reactants were measured, including iron, ferritin, transferrin, albumin, haptoglobin, C-reactive protein, and erythrocyte sedimentation rate.

    • Main Results:

    • Six of the 11 measured acute phase reactants showed an APR pattern: serum iron, ferritin, transferrin saturation, C-reactive protein, erythrocyte sedimentation rate, and haptoglobin.
    • Five reactants (transferrin, albumin, alpha-1 antitrypsin, complement components 3 and 4) did not exhibit a typical APR.

    Conclusions:

    • The study provides evidence that the acute phase response following endurance exercise is analogous to that observed in medical and surgical conditions.
    • Factors such as training adaptation and variability in APR across different conditions may influence the response.
    • This supports the concept of exercise-induced inflammation sharing characteristics with systemic inflammatory responses.