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Is there a vitamin E paradox?

I Jialal1, M Traber, S Devaraj

  • 1Center for Human Nutrition and Division of Clinical Biochemistry and Human Metabolism, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9073, USA. jialal.i@pathology.swmed.edu

Current Opinion in Lipidology
|February 15, 2001
PubMed
Summary
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High intake of alpha-tocopherol (a form of vitamin E) shows promise for cardiovascular health. Evidence suggests it may reduce inflammation and improve outcomes in patients with existing heart disease.

Area of Science:

  • Cardiovascular Science
  • Nutritional Biochemistry

Background:

  • Epidemiologic studies suggest benefits from high alpha-tocopherol intake.
  • Alpha-tocopherol (vitamin E) supplementation reduces lipid peroxidation and platelet aggregation.
  • It exhibits potent anti-inflammatory properties.

Purpose of the Study:

  • To evaluate the evidence supporting alpha-tocopherol supplementation for cardiovascular disease.
  • To synthesize findings from epidemiologic, in-vitro, animal, and clinical studies.

Main Methods:

  • Review of epidemiologic data.
  • Analysis of in-vitro and animal model studies.
  • Assessment of five large prospective clinical trials on alpha-tocopherol therapy.

Main Results:

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  • Four out of five clinical trials indicated a beneficial effect on cardiovascular endpoints.
  • Benefits were observed for primary and other cardiovascular endpoints.
  • Consistent evidence across multiple study types supports a role for alpha-tocopherol.

Conclusions:

  • The overall evidence suggests alpha-tocopherol supplementation may benefit patients with pre-existing cardiovascular disease.
  • Further definitive recommendations await results from ongoing clinical trials.